Ph.D. University of Utah, 1990
Nuclear magnetic resonance spectroscopy
BioInorganic/BioOrganometallic Chemistry, Medicinal Chemistry, Metal-Based Drugs, NMR Spectroscopy
My research work entails the design of metal-based drugs and organometallic biosensors. New metallocene drugs for target specific tumors are developed as tools for treating hormone dependent cancers. To achieve this, steroidal hormones (estrogen, androgen and progesterone derivatives) are attached as pendant groups to the corresponding metallocenes. The mechanistic aspects of these species are studied by spectroscopic methods such as NMR, UV-Vis, Fluorescence spectroscopy, electrochemistry and Molecular Modeling techniques. Another area of interest, in collaboration with the Material and Engineering Department, is the development of electrochemical biosensors. The principal objective of this work is to develop an electrochemical biosensor based on conducting polymers electrode functionalized with ferrocene to detect substrate such as glucose and other biologically important analytes.
“Ferrocenes as potential chemotherapeutic drugs: Synthesis, cytotoxic studies and micronucleus assay” Wanda I. Pérez, Yarelis Soto, Carmen Ortíz, Jaime Matta, Enrique Meléndez, Bioorg. Med. Chem. 2015, 23, 471-479.
“DNA electrochemical biosensor for metallic drugs at physiological pH” Angel J. Santiago-Lopez, Jose L. Vera, Enrique Meléndez, J. Electroanal. Chem. 2014, 731, 139-144.
“The addition of Pregnenolone Group Enhances the Anticancer Properties of Titanocene Dichloride in a MCF-7 Xenograft Model” G. Ramos, Y. Loperena, G. Ortiz, A. Szeto, J. Vera, J. Velez, J. Morales, D. Morrero, L. Castillo, S. Dharmawardhane, E. Meléndez, A.V. Washington, Anticancer Research 2014, 34(4):1609-15.
“Water soluble molybdenocene complexes: Synthesis, cytotoxic activity and binding studies to ubiquitin by fluorescence spectroscopy, circular dichroism and molecular modeling” Xiomara Narváez-Pita, Carlos Ortega-Zuniga, Claudia Y. Acevedo-Morantes, Belinda Pastrana, Jesús Olivero-Verbel, Wilson Maldonado-Rojas, Jaime E. Ramírez-Vick and Enrique Meléndez, J. Inorg. Biochem. 2014, 132, 77–91.
“Functionalized ferrocenes: The role of the para substituent on the phenoxy pendant group” José L. Vera, Jorge Rullán, Natasha Santos, Jesús Jiménez, Joshua Rivera, Alberto Santana, Jon Briggs, Arnold L. Rheingold, Jaime Matta and Enrique Meléndez, J. Organometal. Chem. 2014, 749, 204-214.