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Programas de Investigación


María A. Aponte
maponte@uprm.edu
Professor, Ph.D., University of Florida, 1982.

Development of bacterial polymers as biodegradable materials; biodegradable polymers for controlled release technology.



Mayra E. Cádiz
mcadiz@uprm.edu
Professor, Ph.D., University of Puerto Rico, 1985.

Synthesis of derivatives of cisplatin; synthesis and interaction of platinum drugs with DNA; synthesis of metal complexes as potential antitumor compounds.


Arnaldo Carrasquillo
carrasa@uprm.edu
Assistant Professor, Ph.D., Texas A&M, 1995.

Research efforts are aimed at understanding the role played by electrode surface composition and structure in determining and controlling the electrochemical reactivity of species present at electrode-solution interfaces. Current research projects study fundamental aspects of electrocatalysis and of biosensor technologies. The studies combine the use of XPS, AES, LEDD, TDMS, Thin – Layer and classical electrochemical.


Miguel E. Castro
miguel_castro99@hotmail.com
Associate Professor, Ph.D., University of Texas at Austin, 1991.

Synthesis and characterization of electronic materials; application of heterogeneous catalysis to drug synthesis; time-resolved mass and infrared spectroscopy; time-of-flight measurements of oriented molecules.


José E. Cortés-Figueroa
j_cortes@rumac.uprm.edu
Professor, Ph.D., University of North Texas, 1989.

Synthesis and characterization of fullerene – transition metal complexes. Electronic and geometric structure of fullerene – transition metal complexes and the relationship of their structure with the complexes chemical reactivities. Integration of high school biology, chemistry, mathematics and physics using calculator-based laboratory technology.


Astrid J. Cruz
acruzpol@uprm.edu
Associate Professor, Ph.D., University of Massachusetts, 1993.

Theoretical studies of molecular scattering phenomena by means of wave packets and fast Fourier transform techniques. Quantum finite temperature studies of molecule-surface energy transfer processes.


Marcos A. De Jesús Ruiz
mdejesus@uprm.edu
Associate Professor, Ph.D., University of Tennessee, 2004

Develop advanced spectroscopic and spectrometric techniques for the characterization and quantification of pharmaceutically relevant compounds. Develop new analytical schemes for the detection of pesticides, pharmaceutical and personal care products and other aromatic contaminants in the environment. Study the impact of persisting oprganic contaminants on human health. Characterization of bimolecular systems of pharmaceutical and environmental interest.



Maritza de Jesús
M_J_Echevarria@hotmail.com
Associate Professor, MS, University of Puerto Rico, 1984.

Optimization of CG-MS and CG-FID tropical analysis of thermally labile essential oils in plants. Development of the right analytical methodology as a fundamental prerequisite to assess the biosynthetic capacity of plant cells and tissues cultured in vitro. Methods developments of the analysis of samples of environmental origin.


Emilio Díaz
ediaz@uprm.edu
Professor, Ph.D., University of Wisconsin-Madison, 1986.

Isolation and characterization of oxidative enzymes from fungi; study of role of oxidative enzyme on fungal pathogenicity. Isolation and inhibition studies of Histidine Decarboxylase from microorganisms which contaminate fish and dairy products. Study of the effects of antioxidants on the development of rancidity in frozen Tilapia.


Samuel P. Hernández
sp_hernandez_uprm@yahoo.com
Professor, Ph.D., John Hopkins University, 1986.

Molecular Spectroscopy of crossed molecular beams and jets; Laser-Raman and surface enhanced Raman Spectroscopy of biomolecules and their interactions with heavy metal ions and carcinogenic compounds; molecular spectroscopy of coordination compounds, superconductors, and explosives; theoretical calculations correlating measured spectroscopic properties.


Aidalú de los A. Joubert
ajoubert@uprm.edu
Assistant Professor, Ph.D., Washington State University, Pullman, 1998

Evaluation of Liquid Chromatography - Particle Beam Mass spectrometry as a technique for the analysis of vanadyl geoporphyrins.


Jorge Laboy
jlaboy@uprm.edu
Associate Professor, Ph.D., University of Cincinnati, 1993.

Work on my laboratory focuses on mid – infrared FTIR spectroscopy of transient species and reaction intermediates, mainly radicals using Matrix-isolation. We are also interested in photochemical reactions and reactions dealing with semiconductor materials.


Juan López-Garriga
SONW@caribe.net
webpage:
sonw.uprm.edu

Professor, Ph.D., Michigan State University, 1986.

Research interest: Structure and function relationships in hemeproteins, like the unique hemoglobin I from Lucina pectinata. For example, using “site directed mutagenesis” we tailor the structure of this hemoglobin. Its chemical structure is then studied by Fourier Transform infrared, resonance Raman vibrational analysis, and NMR spectroscopies. This is followed by the kinetic study of the reaction between hemoglobin and ligands (for example, O2, CO, NO, and H2S) using time – resolved (pump and probe) infrared and resonance Raman techniques. Ultrafast geminate chemical dynamics are studied also in our laboratory using time - resolved (pump and probe) picosecond and femtosecond spectroscopy.

Education Interest: Development and implementation of a coherent link between pre-college education and the University (K-12 Outreach Programs University Science Programs). To accomplish this goal I developed the Science Shows and GLOBE programs in Puerto Rico.


Gustavo López
glopez@uprm.edu
Professor, Ph.D., University of Massachusetts, 1992.

Classical and path integral quantum Monte Carlo simulations of the thermodynamic properties of condensed matter systems; ab-initio calculations of weakly bound systems.


Enrique Meléndez
emelendez@uprm.edu
Professor, Ph.D., University of Utah, 1990.

Meléndez’s research work entails the design of metal-based drugs and organometallic biosensors. New metallocene drugs which target specific tumors and receptors are developed as tools for treating cancers.


Nairmen Mina
nmina@uprm.edu
Associate Professor, Ph.D., Baylor University, 1996.

FT-IR, near IR, VIS and photoacoustic spectroscopy of organic compounds at cryogenic temperatures. Chemical Kinetics and Spectroscopy of CRC’s.


Luis A. Morell
lu_morel@rumac.uprm.edu
Associate Professor, Ph.D., University of California, Riverside, 1993.

Organic Synthesis and development of hetero Diels-Alder Reaction. Conformational analysis of sugar derivatives.


Elsie I. Parés Matos
epares@uprm.edu
Assistant Professor, Ph.D., Purdue University, 2000.

Regulation of gene expression by DNA-protein and protein-protein interactions.


Belinda Pastrana
belinda@uprm.edu
webpage:
www.uprm.edu/wquim/facultad/bpastrana/
Associate Professor, Ph.D., Rutgers University, New Jersey, 1995.
Post – Doc Mayo Clinic 1996.

Studies to understand protein-ligand, protein-protein and protein-lipid interactions that have direct clinical relevance following an approach used that is multidisciplinary in nature involving molecular biology, biochemistry biophysics and molecular modeling.


Francis Patron
fpatron@uprm.edu
Webpages: www.fpatron.com
www.uprm.edu/wquim/facultad/fpatron/
Assistant Professor, Ph.D., Purdue University, 1997.

Chemistry education research on the teaching and learning of chemistry, with particular interest in physical chemistry.


Doris Ramírez-Soto
DO_Ramirez@rumac.uprm.edu
Professor, Ph.D., Rutgers University, 1989.

Characterization of the glycan unit of plant glycoproteins; Isolation and Characterization of toxin(s) from R.phaseoli; Isolation and characterization of gibberilins in coffee.


César Reyes
creyes@uprm.edu
Professor, Ph.D., University, of Ottawa, 1969.

Lectins as defense proteins in plants.


Robert Ríos
rrios@uprm.edu
Associate Professor, Ph.D., Rutgers University, New Jersey, 1995.

Organic Synthesis and Medicinal Chemistry. Chemotherapeutic approach to the treatment of tumors and the chemistry involved in the synthesis of those ligands. Methodology development for the synthesis of useful intermediates to be used in the construction of novel chemotherapeutic drug.


Jorge L. Ríos-Steiner
jrios@uprm.edu
Associate Professor, Ph.D., University of Puerto Rico, 1991.

The analyses and structural studies of macromolecules, natural products, organic and inorganic molecules, utilizing X-ray crystallography as the main analytical tool. The primary targets will be proteins, inhibitor-protein and protein-protein complexes, involved in the complex blood coagulation process. Proteins and complexes of other cell signaling and metabolic processes, will be studied as well. The aim is to study their mechanism(s) of action and structural/activity relationships, based on the X-ray model obtained. Molecules are crystallized; data is collected and analyzed; and the structure is modeled into the electron density maps and finally analyzed in detail.


Luis A. Rivera
luir@uprm.edu
Associate Researcher, Ph.D., University of Puerto Rico, 1990.

Synthesis, spectroscopic studies and theoretical correlations of heterocyclic and substituted polycyclic aromatic compounds with potential activity. Analytical method development for trace detection of energetic compounds. Thermal stability studies of substituted polycarbonates, polyesters and other polymeric substances with potential applications as insulation materials in aircrafts.


Cynthia Robledo-Luiggi
crobledo@uprm.edu
Professor, Ph.D., University of Florida, 1981.

Synthesis of oligopeptides containing one or more aromatic amino acids; study of small molecule-nucleic acid interactions; synthesis of oligopeptides with unusual amino acids, synthesis of oligopeptide analogs.


Lolita Rodríguez
lolitar@uprm.edu
Associate Professor, MS, University of Puerto Rico, 1985.

In vitro evaluation of decoctions from plants of reputed ethnopharmaceutical activity to treat kidney stones disease. The project includes measurements of free and complex Ca+2 in solution, dissolution of calcium oxalate or calcium phosphate by plant decoctions, and inhibition of crystal or stone growth by plant extracts.


Félix R. Román
roman_felix@yahoo.com
Professor, Ph.D., University of Nebraska, 1989.

Development of analytical methods for the determination of trace levels of metals and pesticides in biological and environmental matrices.


Rodolfo Romañach
rromanac@uprm.edu
Webpage:
www.uprm.edu/wquim/facultad/romanach/
Professor, Ph.D., University of Georgia, 1986.

Development of near infrared spectroscopic methods for use in the pharmaceutical industry. Development of analytical methods to study interactions between excipients in solid oral dosage forms and tablet surfaces. Continuing Education and Professional/Personal Development of Chemists, and use of polarized light microscopy in chemical education.


Ismael Scott
IsmaelScott686@hotmail.com
Professor, Ph.D., University of Florida, 1985.

Infrared and Laser-Raman spectroscopic studies of RNA and DNA bases, including both experimental and theoretical work; toxicologic and environmental effects of chemicals.


Fernando A. Souto
fsouto@uprm.edu
Professor, Ph.D., University of Alberta, 1978.

Association of organic dyes in solution, equilibrium polymerization, electronic absorption and emission spectra, excitation energy transfer, photochemistry of alkaloids N-oxides, amperometric glucose biosensor, solid-state impedance immunological biosensors. In addition, there is ongoing work with Lippia dulcis Trey: Formation and growth in tissue culture; initiation, growth and viability of calli and cell suspension cultures; production and biosynthesis of terpenes and terpenoids by in vitro cell cultures.


Carmen A. Vega
cvega@uprm.edu
Professor, Ph.D., University of Florida, 1975.

Thermodynamics of solutions. Electrochemistry and spectroscopy. HPLC studies of limits of detection of drugs in physiological fluids. Studies of the interaction of Pt drugs with amino acids and DNA.


Marisol Vera
mvera@uprm.edu
Professor, Ph.D., Purdue University, 1986.

Nuclear Magnetic Resonance (NMR) Spectroscopy: Characterization of oligonucleotide structures and small molecule-nucleic acid complexes by NMR; analytical applications of multinuclear NMR; analytical instrumentation. Evaluation of pesticides in soils amended with compost.


René S. Vieta
r_vieta@yahoo.com
Professor, Ph.D., Texas A&M University, 1984.

Synthetic and mass spectrometry studies of saturated nitrogen heterocycles. Mechanisms of oxazoline formation. Synthesis of diamines that are precursors of cyclic ureas.


 

     
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