Synthesis of derivatives of the anticancer drug cisplatin, cis-[PtCl2(NH3)2].
Development of non-classical analogues of cisplatin in search for new modes of activity.
Use of steric effects to overcome Pt-drug resistance associated to removal of the drug by sulfur containing biomolecules.
Characterization of DNA-adducts produced by platinum drugs Surface enhanced Raman scattering studies of Pt-modified DNA.
Restriction enzyme analysis and gel electrophoresis studies of Pt-modified DNA.
Binding studies using nuclear magnetic resonance spectrometry and spectroscopic techniques.