Organic Synthesis and Medicinal Chemistry. Chemotherapeutic approach to the treatment of tumors and the chemistry involved in the synthesis of those ligands. Methodology development for the synthesis of useful intermediates to be used in the construction of novel chemotherapeutic drug.

 

Selected Publications:

Effect of 6-aminonicotinamide and other protein synthesis inhibitors on formation of platinum-DNA adducts and cisplatin sensitivity. Budihardjo, I. Imawati; Boerner, Scott A.; Eckdahl, Steven; Svingen, Phyllis A.; Rios, Robert; Ames, Matthew M.; Kaufmann, Scott H. Division of Oncology Research, Mayo Medical School, Rochester, MN, USA. Molecular Pharmacology (2000), 57(3), 529-538.

Murine pharmacokinetics of 6-aminonicotinamide (NSC 21206), a novel biochemical modulating agent. Walker, Denise L.; Reid, Joel M.; Svingen, Phyllis A.; Rios, Robert; Covey, Joseph M.; Alley, Michael C.; Hollingshead, Melinda G.; Budihardjo, I. Imawati; Eckdahl, Steven; Boerner, Scott A.; Kaufmann, Scott H.; Ames, Matthew M. Department of Oncology, Mayo Clinic, Mayo Medical School, Rochester, MN, USA. Biochemical Pharmacology (1999), 58(6), 1057-1066.

Synthetic studies relating to ligand interactions at benzodiazepine receptors. Rios, Robert. Rutgers, State Univ., Newark, NJ, USA. Avail. Univ. Microfilms Int., Order No. DA9603555. (1996), 161 pp. From: Diss. Abstr. Int., B 1996, 56(10), 5499.