IRT2: Controlling Crystallization of Organic Molecules in Polymer-Based Formulations

IRT 2 Members

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Torsten Stelzer

Dr. Torsten Stelzer is a professor from the Pharmacy Department at the University of Puerto Rico Medical Sciences Campus.

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Junguang Yu

Junguang Yu is a fellow at the University of Wisconsin and earned a bachelors degree in Materials Science and Engineering at Tsinghua University

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Geoff Zhang

Dr. Geoff Zhang is a professor at the Pharmacy School under the University of Wisconsin.

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Chris Benmore

Dr. Chris Benmore is a professor from the Physics Department at the University of Wisconsin.

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Vilmali López Figueroa

Dr.Vilmali López Figueroa is an assistant professor at the University of Puerto Mayagüez Campus.

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Rodolfo J. Romanach

Dr. Rodolfo J. Romanach is a professor from the Chemical Engineering Department at the University of Puerto Rico Mayagüez Campus.

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Mark D. Ediger

Dr. Mark D. Ediger is a professor from the Chemistry Department at the University of Wisconsin.

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Izabela Szlufarska

Dr. Izabela Szlufarska is a professor from the Chemistry Department at the University of Wisconsin.

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Paul Voyles

Dr.Paul Voyles is a professor from Materials Science and Engineering
at the University of Wisconsin.

Description

IRT 2:

Controlling Crystallization of Organic Molecules in Polymer-Based Formulations  is a project directed by Torsten Stelzer, professor at the University of Puerto Rico Medical Sciences , focused on studying crystallization, polymorphism, and molecular mobility of active pharmaceutical ingredients (APIs) in polymer matrices to develop polymer-based formulation strategies. Experiments and simulations will be performed to characterize the crystallization, dynamics, and structure of APS.

Goal:

The main objective of IRT 2 is the study of crystallization, polymorphism, and molecular mobility of small organic molecules in polymer matrices. This work will lead to the development of polymer-based formulation strategies for high-quality products with advance materials properties.

Composed by three projects:

Crystallization and Polymorphism of APS:

Team:  Dr.  Stelzer, Dr. López, Yu. and Dr. Zhang.

Dynamics in APS:

Team: Yu, Dr. Voyles, Dr. Santiago,  Acevedo and Ediger.

Structures of APS:

Team: Dr. López,  Dr. Stelzer,  Yu,  Dr. Voyles, and  Dr. Benmore.

Role of Partner Institution & Collaborators:

Collaboration is critical for advancing the research in IRT 2 through vital discussions and exchange of ideas on nucleation, crystallization, and polymorphism as well as on specific API-polymer interactions. In addition, the collaborator (AbbVie, G. Zhang) provides industrial relevant perspective.

Accomplishments:

In Y6, IRT 2 accomplished one (1) publication, two (2) manuscript submissions currently under review, five (5) conference contributions, one (1) currently under review, one (1) NSF award, participated in two (2) open house/science expedition activities, and initiated collaborative research to support the IRT2 materials characterization with machine learning.