Powder compression in rotary tablet presses is used as a major step in the manufacture of pharmaceuticals, cosmetics, catalysts, personal care products, military ordnance, etc. In powder compaction applications, consistent flow of powders into the small die of a tablet press is key to producing tablets with consistent properties. Manufacturers often use mechanical devices, called “feed frames” or “feed shoes” to maintain an adequate supply of powder to fill the dies of the tablet presses. The scope of this project includes the development of effective methods and equipment for continuous feeding of pharmaceutical powders as well as to investigate processing conditions and their powder effects. Through the use of experimental results and DEM simulation, powder phenomena and feeding performance for the two different feed frames (the Manesty Beta Press and the Fette 3090) with different production scale will be investigated.. The experimental data will be used to validate the simulation results using the RTD function. The present work has being developed as part of the Engineering Research Center (ERC) for Structure Organic Particulate systems.