Chemical imaging is an innovative technique that uses conventional imaging and spectroscopy to obtain spatial and spectral information from a sample. Near Infrared Chemical Imaging (NIR-CI) unites the chemical selectivity of vibrational spectroscopy and the potential of image visualization. The combination of both aspects creates a more complete instrument which can be applied for the determination of ingredient distribution in solids, semi-solids, powders, suspension and liquids [1]. The principal industry where NIR has been used is in pharmacology, for non-destructive studies of the ingredients distribution in the whole surface of a tablet in a designed range of special resolution. [2] Specifically, chemical imaging is the arrangement of microscopes and vibrational spectrometers to create a 2D image of a sample. Ideally, it shows a mapping or true image of the components of the analyzed sample based on their chemical composition and spatial location. [3] Each pixel contains a spectrum in that position. The image is a three-dimensional block of data with two spatial and one wavelength dimension [1]. This block is called a hypercube. One acquisition saves thousands of images across different wavelengths. A single image plane illustrates the absorbance of the sample at a particular wavelength. [4] A three dimensional image can be constructed by two methods. The first is known as pushbroom acquisition. In this particular method simultaneous spectral measurements are taken from series of nearby spatial positions and the sample is moved underneath the instrument. This technique has been applied with Raman. The advantage of this technique is that it is able to take the spectra of the entire sample without touching it or moving manually. The second technique known as staring imaging configuration the instrument keeps the view of the image fixed and the images are taken one wavelength after another, Near Infrared Chemical Imaging (NIR-CI) is an example of this [1]. The principal advantage of this method is that it does not need any moving part over pushroom. Chemical imaging is a multidisciplinary technique that combines two important aspects spectroscopy and signal and image processing [2]. Finally NIR spectroscopy is a strong and adaptable technique that can be adopted for use in a wide range of chemical analyses in several different research and industrial applications. The extra information provided by technique presents access to superior understanding and hence control of the manufacturing process of complex composite materials and products. [4] [1] A. Gowen, C. O’Donnell, P. Cullen and S. Bell. “Recent applications of Chemical Imaging to pharmaceutical process monitoring and quality control”. European Journal of Pharmaceutics and Biopharmaceutics 69, 10–22, (2008). [2] J. Amigo, J. Cruz, M. Bautista and S. Maspoch, J. Coello and M. Blanco. “Study of pharmaceutical samples by NIR chemical-image and multivariate analysis”. Trends in Analytical Chemistry, 27, pp. 696-713, 2008. [3] S. Sasic. “Chemical imaging of pharmaceutical granules by Raman global illumination and near-infrared mapping platforms”. Analytical Chimica Acta. 611, pp. 73–79, 2008. [4] K. Bakeev Process Analytical Technology, Blackwell Publishing, 2005.